Vitamin k2 mk4 vs mk7 reddit gov/30816822/ (mk4 0. The Mk7 also I upped my vit K2 (both mk4 and mk7) intake and spread it out during the day, because mk4's half life is only 1-2 hours. When we speak of the vitamin K2 subtype, there are several known species. The MK4 supplements are synthetic. The rest of my supplementation regimen did not change and I took it at the same time (dinner) For 5000 IU D3, Vitamin K2 MK-7 at 50 mcg, 75 mcg or 100 mcg? Haven't been able to find a proper answer, I am trying to take the lowest amount possible of Vitamin K2 to avoid potential heart palpitations, but I don't know what is the Use a low dose of vitamin d and k2 mk4. 5mg MK4, 300mcg mk7, 900mcg vitamin A, and 5000IU D3. Considering these actions, Vitamin K2 (as MK-7) was tested in naturally aging rats as a potential nootropic. because you aren't going to get 5mg of K2 MK4 from food and if you are taking megadoses of D you need that much to prevent adverse events https://pubmed. Vitamin MK-7 in the ND supplement is What is the Difference Between Vitamin K2-MK4 vs. Easy to come to wrong conclusions. Most of the time it does not cause symptoms. 2 ng/ml ± 0. Listen to Andrew Saul and other orthomolecular doctors. Thorne liquid K2 MK4 drops seems to be the only way to go, just so many little unknowns and little problems with MK7 You have to take it often, at least a few times a day but you can control the dosage and the $60 bottle will last 8 months if you do 5 If it works, 1 mg/kg vitamin K2 MK-4 split across 3 servings (each 6 hours apart). I don't mind if calcium or other minerals are also present. The Jarrow people say this about their mk7: MK-7 FunctionSupports Bone and Cardiovascular Health* MK-7 Highlights Vitamin K2 as Menaquinone-7 Softgels Superior Form of Vitamin K Longer Half-Life Than K1 (Days vs. I take 45 mg of vitamin K2 the MK4 type due to dental. gov/23140417/ MK-4 supplementation did not increase serum MK-4 levels. Both have their benefits which I need and want. I feel this helps with possible calcification of arteries from my taking vitamin D3 as prescribed (mk7) and putting into strong bones and also teeth health (mk4). I took Vitamin K2 (MK-7) consistently for a week before I noticed unusually strong palpitations. MK4 behaves differently then MK7. 1 pill is 100 mcg mk4 and 50 mcg mk7. This is a main reason that dosages of MK-7 may be as low as 45 µg daily and that single daily dosing is possible. My doctor has me taking 10,000iu of D3 three days a week and has said I get plenty of Vitamin K in my diet . Doing the math you will notice that beyond 5,000 IU D/A this gets pricey and we don’t know if increasing the dose of D necessitates an ever-increasing dose of K2 or if the demand and benefit caps out at some point. Palpitations are, sadly, MK7 doing its job. I don’t intend to pack it back like in the studies but there is little point in spending a lot of money taking a tiny amount. Sunshine 15-30 min 2x/wk for the D. I think the main thing with K2 is understanding MK7 vs MK4. I get swollen dark eyelids from them. Very simply: D3 raises calcium levels and K2 transports it into bones, so they must work together. The Basics of Vitamin K2 Vitamin K2 is a group of compounds known as menaquinones, with the two most common forms being MK-4 and MK-7. Vitamin K2 MK7 supplements fail to slow calcium buildup in heart valve (from Vitamin D) it's almost impossible to find MK4 (at least in Canada). I was only taking 5,000-10,000 IU D with about 200 mcg of K2 and was dealing with heart palpitations, insane insomnia (easily didn't sleep for like 48 hours), anxiety, low appetite etc. What I thought I remembered Rhonda saying was that vigorous exercise basically pushed Most of the impressive studies showing the benefit of K2 is the MK4 form. I started mk7 with daily 45mcg and had the side-effects after 3 days Not everyone can take mk7. /day is insufficient for fracture prevention, 800-1000 i. I'm very reluctant to take MK7 due to all the reports of heart palpitations after starting MK7 specifically, so I'm just going to stick with MK4 even if I There are significant differences between them: in paticular, MK-7 has a longer half-life, so a smaller dose can be used. Get the Reddit app Scan this QR code to download the app now. Son_of_Neptune_ • Get one that's mixed. Thorne multivitamin has gone exclusively mk4 now. So if you're not super loaded go MK7 or a combo vitamin K supp. So, I wanted a Chest x-ray came back normal, no blood clots, calcium levels are normal. Studies have shown that Mk7 supplementation is more effective than Mk4 supplementation at increasing liver Mk4 levels. I tried both and only the MK-7 worked. Take MK4 not MK7, lots of people experience side effects So for 200mcg k2 from mk7 you’d need 2000mcg from mk4. That said, you can take MK4, but the dosages have to I use a full spectrum k2 that has both mk7 and mk4. yeah i meant even online. But h pylori need vitamin K2 for energy synthesis. I've also heard MK4 has some unique benifits that MK7 doesn't have, so I wanted to take a combination MK4 + MK7 if there is such a thing. " Source: https://pubmed. I get pressure like feeling in my throat from the vitamin K2 MK7 supplement. Mk-7 is one molecular form (homologue) of K2. Genetics is different from everyone, some get reaction even People with high levels of inflammation tend to require higher doses but MK7 can be a problem at those levels. I am just trying to see how people personally benefitted from MK4. But, maybe the research has changed since I last checked. They also get K2 MK9 from traditional fermented cheese. This is interesting. Magnesium is more important than vitamin K2. They both work the same way. If you could only take one form of K2 I’d say this If you are more concerned with labs take MK7. There are so many forms of K2 out there. I also commonly see 200mcg mk7/2000mcg mk4 recommended if supplementing over 2500iu vitamin D3. K2 as MK-7 or MK-4 . While these two nutrients are both menaquinones, there are some significant differences in their structures that impact how long they remain Both MK-4 and MK-7 supplements can have cis or trans isomers, depending on the method of manufacture. I know many say mk7 is good but what I found on various articles was that mk7 is relatively new and reason it's good is cause of it's potency to increase serum level fast but many say mk4 is better and is used up fast thus seems less crucial but isn't. I had been taking a Vitamin D& K2 (mk-7) supplement for a couple months and only recently connected it to the crazy anxiety symptoms I have been experiencing. This could be part of how statins cause calcification of plaques. But i keep hearing i have to take all this extra other crap along with it and im so confused. From my understanding, mk-4 seems to be the most tested form, responsible for benefits displayed in many clinical trials. Will be taking a weekly d3 megadose post lab work showing severe deficiency (14L) How much K2 (MK4) should I supplement with? Chose this form based on feedback around MK7 giving some people heart palpitations and know half life and dosage may differ K2 is a general term for the vitamin. I've had Vitamin D3/K2 that made me feel sluggish in the past, but this had MK-7 in it. I do have NOW's D3 5000 IU, 240 count as a backup, but no backup K2. I’ve heard that 100mcg mk7/1000mcg mk4 is enough for general health. If it is pointless to supplement this small amount, I won't buy the MK4 anymore. I am not looking for research on MK4. Weston Price goes through lengths to explain why you need only mk4 and not mk7. Warning - do not supplement in calcium if you take a fair amount of vitamin D3 and K2 as they increase the absorption rate of calcium highly! taking K2 with D3 prevents calcification of calcium. K2 helps bones and heart. The body can transform mk7 in mk4. Or the K2 being used is mk7, not mk4. You have to do the Triple Play of Vit D, Vit K2 and the MagOil (magnesium chloride flakes made into a skin spray) or you could end up with negative effects, but following the 1:10, K2:VitD ratio, and using the spray on my body has changed my life. What were the doses you took if you have any negative effects? I was taking 100mcg. Vitamin K2 (MK-7) answersfound; Mar 14, 2015; Supplements, Pharmaceutical Drugs; Replies 19 Views 6K Posted by u/Conspiranut - 479 votes and 139 comments The rule of thumb I go by is equal amounts of A and D with 100 mcg K2 (as MK-7) per 1,000 IU A/D. 2 mg K2-MK7 (which they say is valuable because it persists in the blood so much longer, for uptake wherever needed for 72 hours after ingestion. The two most commonly commercialized forms of Vitamin K 2 are MK-4 and MK-7. Mk4 or Mk7. K2 MK4 definitely works, you just need to supplement it more often and at higher doses in the mg range compared to the standard mcg dose sold in a lot of brands. MK4 on its own has worse bioavailability, and a very short half-life. g. For your case, with 5000 IU of vitamin D3 daily, you might consider taking 100-200 mcg of vitamin K2 MK-7. (In my opinion). I am currently taking MK4,but wanted to try MK7 again, but at a lower dose. Old. Beef liver 2x/wk for the Vitamin A. Pseudoscience and dry labs on Vitamin K (MK4 and MK7) and fracture risk -- fraud exposed at the highest levels of nutrition science upvotes · comments r/Supplements When searching for K2 supplements on amazon or the Vitamin Shoppe physical store, what forms do you look for? Found a reddit post about Mk4 vs Mk7, not sure if the bottles will say which it is most of the time However, a commonly suggested ratio is around 100-200 micrograms (mcg) of vitamin K2 MK-7 for every 1000 IU of vitamin D3. The MK4 form deposits into some places that MK7 can't go like the brain because it's a smaller molecule. I take 5mg with lunch/dinner and I have found it makes a huge difference in how I Hey sorry I'm late to the party. Happy for your feedback as I am new to taking K2. These fat soluble vitamins along with magnesium work together. 8 percent from The best food sources of Vitamin K2 are grass-fed dairy products, emu oil, gouda, brie cheese, and natto, a very strong-tasting fermented soy product with roots in Japan. a couple of hours for MK-4), but at least for me, personally, I found trying out MK-7 gave me heart palpitations. 30. :) I myself take 200mcg mk7 daily ( ~100mcg for 2 years and 200 for 4 months ), 1mg mk4 (4 mon) and haven't noticed any effects on greying. Glancing at the studies on examine, MK7 might be a bit better for bone health, whereas MK4 is good for cancer (no studies were done for MK7 and cancer). I have been taking 100mcg MK7 and about 1mg MK4 a day. K2 competes with D3 for absorption and should be taken 3hrs or later after taking D3. Most people have h pylori in their system. Any Vitamin K2 is likely derived from a food product that is high in histamine and your body may be reacting to that. I'll stick to a bit of hard cheese then for vitamin k2. They become healthy and strong, and start to wreck havoc on your There is one on Amazon US with the label: "Ultra High Vitamin D3 20,000 IU + K2( MK7 ) 200mcg - Once Daily Dose, Optimal Level - Support Bone, Joint, Heart, Immune Health, Helping Vitamin D Deficiencies, Easy to Swallow,240 Servings Softgel" that provides in one capsule, 20,000 iU of Vitamin D3 and 200 micrograms of Vitamin K2 MK7. Is it possible that Vitamin K2 MK7 caused it? I take 180mcg a day, 5000 IU Vitamin D Magnesium and Vitamin C. Try the Mk4 version. 3 doctors and 2 pharmacist said i didnt need k2 or anything else because im deficient on vitamin d and i was given a mega dose to bring that back up so i didnt have to That class is made up of vitamin K1, as well as vitamin K2 and vitamin K2’s 10 subtypes, known as MK-4 to MK-13. The western diet contains hardly any vitamin K2 and the calcium to magnesium ratio is three to one. Getting Enough Vitamin K2 in the Diet View community ranking In the Top 1% of largest communities on Reddit. I was wondering which source of K2 supplement is better mk4 or mk7 and what dosage for each and how frequently. Any recommendations? NEW PRODUCT RELEASES ARE COMING 2/2/23 | Vitamin D3 + K2 (MK-4) & Three New Mystery Products. I was already on Dustastride and 1. Your trusty research source would be better than my explanation. I was put on 50,000 d2 and i have been only taking that once a week. So I would suggest cutting off k2 mk7 and only sticking to k2 mk4. Another one that compares 1mg k1 vs 45mg k2 mk4 Vitamin K Treatment Reduces Undercarboxylated Osteocalcin but Does Not Alter Bone Turnover, Density, or Geometry in Healthy Postmenopausal North American Women Reddit Pinterest Tumblr WhatsApp Email Change in serum vitamin K 2 levels following a single oral dose (420 μg) of MK-4 or MK-7. Baseline serum level of MK-4 was 2. I take 50 to 100 mcg of k2 mk7 daily and once a week I take 3-5 mg of Thorne k2 mk4 liquid drops. After some trial and error, to solve the cost problem of MK4 vs MK7, I use the throne MK4 liquid drops. Vitamin K-2 - 200mcg. That seems like a massive amount. Also we have bacteria to convert short chain K2 to long chain, the opposite isn't the case. The MK4 variety is much better tolerated even in very high doses 45mg not mcg. I tried natural factors What most people don’t know is that the half life of mk7 is insanely long, so it builds up in your system. If you have found MK4 beneficial, please post your Personal Experience only, if you are taking additional supplements with it please do mention those too. It raises my blood pressure slightly, can cause a tight chest feeling, and can disrupt my sleep if I take it daily. nih. MK4 gets taken up very quickly and does not circulate for days unlike MK7. Or check it out in the app stores K2 - which form? MK4 or MK7? Controversial. MK-7 is absent in the brain. However, one of the things I've noticed is that, since starting to take it, my libido has been exceptionally high. MK7 - posted in Dental Health: I just wanted to post something anecdotal on this forum. I have not tried mk4. Research using the MK-7 form of vitamin K 2 began about a decade ago. May be worth looking into this for some of you. You are a bit confused here, so lets be VERY clear. Or check it out in the app stores can i take both vitamin k2 mk4 and mk7 together? i bought mk7 and mk4 together recently, i megadose mk4 45mg and mk7 i bought is 150mcg, i was planning on starting to take MK7 after im done with MK4 but i was wondering if i can Be careful with MK-7 (form of Vitamin K2 in most supplements), caused anxiety + hypertension for me I took 100 mcg of MK-7 (now™ brand) for two days (yesterday and the day before) and since yesterday have been experiencing crazy anxiety, along with spikes in heart rate up to 130 bpm (from a normal resting rate of 55-60) and spikes in blood pressure up to 140/95 (from a normal You can buy vitamin K2 in 2 forms mk4 or mk7 or a combination. In many, myself included the MK7 type causes issues. Synthetic MK-4 supplements don't have side effects because they don't work. Each point represents the mean ± SEM of 5 subjects at 0, 2, 4, 6, 10, 24, 48 and 72 h. The only downside with mk4 is you need to take it at least twice per day. It's not very common to have side effects from vitamin K2. I’m not sure if k2 deficiency is actually something you can I started taking vitamin K2 (MK7) a few weeks ago in an attempt to possibly speed up some bone fractures I had from a fall a few months ago. Do you know what Vitamin K is used for? It works in tandem with Vitamin D and calcium, but more so vitamin D. Also, there’s no known toxicity or ld50 from vitamin k2, mk7, mk4, at any dosage. 86; 95% CI, 0. Is the mk4 version of k2 even absorable? The studies showed mk4 when supplemented didn’t increase mk4 in body but mk7 did increase mk4 stores in body. Too much diarrhea. EDIT: The studies tend to use a very high dose for MK4, so MK7 might be the better value option. It seems this product was just released December 8th, it's about 30% cheaper than thorne's k2 mk4 liquid (30ml) in terms of price per mg of mk4, except it also has essential minerals that work synergistically with mk4 and d3. What K2 to take: MK4 or MK7? There are several subtypes of Vitamin K2, and two of the more common options are MK4 and MK7. Fourth most abundant form in the body. Vitamin K2 (MK 4) is different than K2 (MK 7) and K1, as it is poorly absorbed orally, and the liver tries to get as much of it, as it can, so it gets concentrated in the liver mostly. As far as I know, only supplemental MK-4 has measurable effects on steriodogenesis (and other things like the mitochondiria ETC) - not supplemental MK-7 which pretty much only affects the bones. mk7 is better at arterial decalcification. For example, MK4 contains a four-carbon tail, and MK7 contains a Likewise for vitamin K2, the risk of an ASCVD‐related hospitalization for participants with the highest intakes was 14% lower than participants with the lowest vitamin K2 intake (hazard ratio, 0. , prednisone, dexamethasone, prednisolone),[17][18][19][20] anorexia nervosa,[21] cirrhosis of I recently ordered some 100mcg Vitamin K MK4 and read afterwards that it is apparently inferior to other forms of Vitamin K and doesn't actually have any effect at all. View community ranking In the Top 1% of largest communities on Reddit. Meditate, humming, little jogging, heaps of water, 30mins sun, I take a magnesium with htp but I think htp is bad, it's a deep sleep capsule, take like the normal multi vitamins with probiotics, take an additional set of b vitamins for energy, and at night I also take The vitamin d wiki article dosage comes from an interview with Kate Rheume Bleue; she thinks people need 100mcg k2 (mk7) per every 1000iu d3. I take 2 pills twice a day. But according to this article, k2 MK7 is not generally recognized as causing heart issues. December was my third bottle, which I didn't finish, given the side effects. I have done that on K1 and all K2s thoroughly in last 3 months. Vitamin K2 also activates the Vitamin K-dependent protein, Gas6, which also has a neuroprotective role. The present study used 100 µg once daily. MK-4 is the only K2 in the brain. MK7 is produced from natto bacteria. 1mg). Anyways, a study It seems like every online health site (along with many posts on this subreddit) suggest that supplementing with K2 (either MK-4 or MK-7) is necessary if you're taking Vitamin D. Just doing the best we can with the knowledge we have, so many things change even month to month at this point lol. Question is, would it matter which vitamin K2 it is? Personally I don’t really want to supplement, and my diet consists of 2 eggs daily, cheeses and meats throughout the day. Both MK-4 and MK-7 are essential for activating proteins that regulate calcium In theory it doesn't matter whether your vitamin K2 is MK-4 or MK-7. This is a Because there are more studies on MK4, but studies show MK7 can effectively increase MK4 levels in the body, and it lasts far longer. In other words, vitamin K2 feeds them, and you get a population explosion. 81–0. The Mk stands for "menaquinone" and the number after Mk refers to the length of the side chain. 1 million in 2023 and is projected to grow at a CAGR of 10. Finally, the function in the human body appears that MK-7 has all of the functions of MK-4, with a longer half-life (Schwalfenberg, 2017). Calcium is important for the contraction phase of the muscle fibres, while magnesium is important for the relaxation phase. No more itching, no more burning, no more arms and legs covered in plaques. The half-life of mk4 is 1-2 hours while 2-3 days for mk7. There is some anecdotal evidence though. February was my first bottle. Curious how many here supplement with vitamin K2, and if so, what the Discussion of the various vitamin K2 supplements on the market with a comparison of MK-4 from animal sources or MK-7 from bacterial fermentation to ensure the diet contains sufficient amounts of this elusive yet critical nutrient. MK7 is better but both are needed By studies, most successful ones used 180 to 360mcg of MK7 per day or 5 to 15mg of MK4 per day Yes, with large dose of magnesium, at least 300mg, at least 2000 UI D3, and at least 500mg of taurine It seems like MK7 is what we should be supplementing with, but is MK4 useless in smaller amounts? Like 1mg-2mg a day? I have seen people say they take upwards of 45mg a day. Vitamin K2-MK4 (menaquinone-4) and vitamin K2-MK7 (menaquinone-7) are two of the most well-known and well-researched forms of vitamin K2. A little bit down the page, it explains that MK-4 and MK-7 exist in different areas of the chylomicron, and that MK-4 is sent off to different tissues much faster, while MK-7 hangs in the liver, and preferentially gets sent to bone. Another redditor said taking 5mg of K-2 improved their VS significantly. I hope this helps you guys. You will just convert MK7 into MK4 anyway. I started 120 mcg of Vitamin K2 a month ago as I tested deficient for it. Problem with MK4 is that it’s very poorly absorbed so you’re probably not getting enough K2 to have much of an effect. theres another product that has 1mg K1, 1. mk7 is absorbed I've recently stumbled upon the idea that vitamin K2 is important, and has benefits for cardiovascular health (prevents calcification of arteries) as well as bone health. However, I take just 100mcg vitamin K2 MK-4 in the morning and feel incredibly energised. If I do find any, usually it's weak on d3 or k2. The MK7 can cause blood pressure and/or arrhythmias in my and others experience. The version I'd tried was part of a multivitamin, and it was "only" 45 mcg but I've taken other standard multivitamins before, without Vitamin K2, and never had that issue. However, Kate Rheume Bleue suggests that we should supplement 100mcg mk7/1000mcg mk4 for everyone 1000iu vitamin d3 we The second reference was a mouse study that didn't include MK7, only MK4 and MK9. Much appreciated! The MK7 form last longer in the blood stream due to it being a longer molecule thus taking longer to assimilate. I was about 5000iu of d3 and about 45 mg or k2(mk4). This means that higher doses of MK 4 are needed to be used, for systematic benefits (1000mcg / 1mg +) compared to MK 7 (100mcg / 0. gov/8122528/. I take mk7 every 3 days cause of it's long half life. Everything is "MK-7 for best absorption!" djpurity666 • Additional comment actions. My dose for lamotrigine is probably the main one. Another category of vitamin K nutrients is vitamin K2. Hi, I took 200mcg of vitamin K2 MK7 on Saturday from a respectable brand. I've got recently a k2 mk7 supplement dosed You are right, Vitamin K(2) mk4 has little effect on DXA-BMD. My vitamin K-2 is in MK-7 form, natto derived, Naka brand, have no problems with it. It takes 5 half-lives to eliminate it. There is no upper (toxic) limit to vit K2 and one can buy megadoses if one Get the Reddit app Scan this QR code to download the app now. Might be allergic. So I’d say my vitamin K2 MK4 doses surpass the 100 micro grams mark. When that's used up, I'm going back to MK-7, but a lower dose of 45 mcg. Magnesium glycinate is a good option. But just to add something more useful to this reply/thread, you don't need more than 5mg of K2-MK4 per day because it's shown just as productive as 45mg https://pubmed. Did Peter ever say if he takes K2 with his daily D3 supplement? Vitamin K2 MK4 vs. General Question MK4 is the most efficient form. The k2 in food is not the same as k2 in supplements, and hasn’t been shown to have the same effects on the body as mk7 and high dose mk4. Recent research published in science in 2012 initially reported a brand new discovery, and that was that in human brain cells, Vitamin K2 improves the production of energy in the Most people take their D3 with breakfast and K2 at dinner time and this seems sensible, as some research shows that D3 is more effective if not taken at the same time as K2. MK-4 is the synthetic form of vitamin K2, while MK-7 is the natural form produced by bacteria in our gut and found Would love an update on how your hair is reacting to high doses of LE K2 45mg . Again, it's in mice, not humans. The thing is that K2 takes 24-48 hours to mobilize so you could even take it alternating days. These two forms differ in their chemical structure, absorption rate, and function in the body. MK-7 supplements have side effects because they work. May was my second bottle. The heart palpitations are from taking too large a dose. It's up to 150 a day now for last few weeks. 200mcg dose. Vitamin K2 as MK7 was also well tolerated by all patients. The pitfalls regarding MK7 are where the problems lie MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have. There are also A form of vitamin K-2, known as MK-7, naturally derived from fermented soy beans and used in supplements is better at raising vitamin K levels than supplements with synthetic K-1 or synthetic K-2, known as MK-4. Each of these molecules contains a side chain, like a tail, of carbon atoms. MK-4 manages inflammation in the brain. I vote for both as well. Absolutely worth checking this out Vitamin D3 - 125mcg. I suggest Life Extension low dose 45 mcg K2 MK-7. This contains MK4 and MK7. So that tells me the body is quickly using the MK4 form. K2 mk4 is also very good/safe in higher doses according to some studies. That means that MK4 needs to be taken frequently. Likely due to its longer side chain conferring greater liposolubility, MK-7 has a much longer half-life than MK-4. Further, a multicentric placebo-controlled randomized double-blind trial can clearly establish the effect of vitamin K2 as MK7, also in case of residual neuropathy. Due to their longer duration in the body, most common dosages are sufficient to take every 2 to 3 days Vitamin K2 MK4 is a god send! I started taking this less then a week ago. They both have pro's that other form doesn't have. I don't have a set date for that, but I want to make sure it is perfect before we release. Within an hour or so I started experiencing tightness in my chest and breathing didn’t feel natural. Internet Culture (Viral) I have been taking D3 and Vitamin K2 with MK4 & MK7 and found my cholesterol had been skyrocketing and stumbled across multiple NIH studies that found MK4 can raise your cholesterol. Thus, it proves that vitamin K2 as MK7 offers a confirming therapeutic effect in PN due to VBD or T2DM. gov/32244313/ I also searched a few other studies and most studies actually helped with bone related problems including fractures. The sole advantage MK-7 (+ other long chain K2) seems to be its much longer biological half-life (which itself can be a disadvantage if you take too much). However, mk-7 seems to be the form that most people here after doing research it seems mk7 is converted into mk4. Is 500 mcg of Vitamin K2 MK-4 with 100 mcg of MK-7 a good and/or safe mix? That is where the MK7 type has some benefits because it remains in the blood stream for days and is slowly converted to MK4. I'm probably not the best person to follow regarding K2 since I am not being very consistent. Many studies on Vitamin K involve increased testosterone and cognitive functioning, and many people recommend it with Vitamin D and MK4 (or MK7) will not affect It still seems that the consensus is that MK-4 has a relatively short half-life and is only effective at doses >1500mcg/day. I can now look at blue skies for the first time in years. There's a case study out there about a woman that had VS caused by a vitamin D I recently ran out of my MK-7 (I don't know what strength it was, sorry) and quickly bought some MK-4 locally that is 500 mcg and I take one daily. just discovered this! Vitamin K2 can cause h pylori overgrowths. EDIT so a japanese study says 45mg of k2 mk4 prevents osteoporosis and removes calcium Get the Reddit app Scan this QR code to download the app now. Vitamin K2 MK7 edit: do your research on which version is better (MK4 vs MK7) Reply reply Edit 2: holy shit I’m a dummy this is why you should always take Reddit posts w a grain of salt, could literally be a 12 year old behind the keyboard. It is just my opinion, but trying a high dose of k2 in the mk4 form would probably be beneficial to you. However, I haven’t seen any studies that back this claim. Half in am and half in pm. This is probably why I’ve had no problems on a keto diet taking 10K iu vit D and 180mg of vit K2 MK-7, my boron supplement also has ~50mg of calcium. Would it be logical to supplement Vitamin K2 then? However I read this article saying Vitamin K2 MK4 had no effect. Internet Culture (Viral) Amazing Vitamin K. Two newer forms of MK-7 are available that are synthetic. 91). However, vitamin K2 in food exists only as trans isomers, which are biologically active. In the last month since starting it I have shed a large amount of hair and have noticed significantly increased androgenic effects. MK7? Vitamin K2 is a group of vitamins known as menaquinones. Magnesium daily. Due to its side chain, MK-7 has a much longer half-life in the body than MK-4, allowing it greater access to tissues beyond the liver. K2 MK4 and K2 MK7). Most abundant form in the blood. Subtypes differ in molecule chain lengths from 4 units to 15 units, thus named as vitamin K2-MK4 to K2-MK15. I take it at the same time, especially with mk4 because it's short half life. Reply reply purpleishshoelaces I broke my foot on MK7, so I switched to MK4 as I do not trust MK7 as being good enough anymore. Further, the serum half-life of MK-4 has been shown to last a few hours compared to a 3+ day half-life for MK-7. Usually it is the synthetic high dose MK-4 supplements that have the inactive cis MK-4 is the synthetic form of vitamin K2, while MK-7 is the natural form produced by bacteria in our gut and found in fermented foods. I react allergic to cacao, turmeric, cinnamon also. The body can convert Mk7 into Mk4, Mk8, Mk9 and Mk10. This only discusses MK-7 I believe. It was found that Vitamin K2 significantly inhibited oxidative stress and inflammation, while also improving cognitive and emotional New Research on vitamin D: 400 i. According to this study it appears there is a U shaped curve for Vitamin K2, with 60-75uG being the optimum for atherosclerosis and Ischemic heart disease, which seems to worsen with rising intake beyond this dosage Vitamin K, particularly vitamin K2, represents a significant segment of the vitamin market. MK4 is They aren't taking any chances, so they include 1 mg of K1, 1 mg of K2-MK4 and then . Vitamin K2 is a maybe in my book and then the MK4 type. Because Vitamin K2 has been shown to boost the production of energy in brain cells. 25 mg oral minoxidil and find surprising that K2 MK7 could outweigh the effects of those. MK-7 does not I've been taking jarrow mk7. . I reformulated Inifini-B again to tweak it a bit. I eat clean and train each day. Maybe synthetic MK-4 works for that. In short, it is clearly shown that MK7 can’t upregulate all the same important cellular machines as can MK4. The reasoning being that Vitamin D increases calcium absorption, and Vitamin K2 helps direct calcium to bone and teeth rather than to arteries. Make sure you buy k2 MK4 not MK7 as MK7 is a less bioavailable form and is not very helpful. Add to that life extension is also a much-respected brand like Thorne. Either way, if you're taking MK7 - you could also try just taking the K2 every few days instead of daily (as MK7 stays in the system for 3 days, whereas MK4 is only a few hours). I take daily 180mcg of mk7. “Vitamin K is a class of vitamins, like citrus fruits are a class of fruits I've heard that 100 - 200 mcg of K2 MK7 is recommended, but I don't hear much about how much of MK4 to take. I have seen people take between 600-3,000 mg a day. Vitamin K2 Innovixlabs Brand with MK7 and MK4 2x/wk. In my opinion unless you have a vitamin K2 responsive disease you do not need to take any. =MK-4; =MK-7. Vitamin K1 is naturally abundant in many vegetables and can convert to K2 in small amounts, and gut microbiota can also produce K2, but it would be unnatural for early peoples to get 100mcg+ of MK7 or 500mcg+ of MK4 through K2 only, not with any other vitamins like D3 or anything. In fact, the global vitamin K2 market size was estimated at $421. The K2 removes calcium plaque from the arteries. Get the details in the Review of Vitamin K MK-7 stays longer in the blood, and for using MK-4 dosage should be higher. The Japanese also have the longest lifespan. Reddit Pinterest Tumblr WhatsApp Vitamin K2 loosens calcium plaque in the arteries and releases it into the bloodstream. All of the stories about MK7 on reddit are anecdotal, N=1 experiences. I only have about 10 days left. Personally I believe there are benefits of taking MK7. Never had a problem until bottle 3. Full spectrum Vitamin E 2x/wk. 38 and that of Vitamin K2-MK4 vs MK7. MK-7 supposedly has a longer half-life (something like a couple of days vs. My health was pretty good and sleep was easy and restorative. u. The throne supplement I use has 5mg of mk4. Or check it out in the app stores TOPICS. MK4 supplements don't have side effects because they don't work. Study 2. See if this helps. Vitamin D pulls calcium in the blood getting it ready for transport, and Vitamin K directs the calcium where it needs to go (bones and teeth), but also removes it from areas it shouldn't be (arteries, kidney stones, gallstones). The 3rd reference said MK4 dosing in women is never detected in the blood, where MK7 increased. Mystery Product #1 Hints: This precious material was once mentioned in a book from the Song dynasty which describes foreign countries and their associated products of People recommend K2 at the lower doses because they assume K2 is better than K1 (no real evidence of this, in fact MK4 has a shorter halflife) and MK7 is more expensive than MK4 due to it's longer half-life. My VS was pretty bad I couldnt look at the sky at all for years. That helps put calcium in your bones. Many research studies have proved MK-7 is best absorbed into the body and stays long. I’m wondering if anyone here has researched it? Most of my attempts to find some turn out to be the MK7 variety (already have some), and when I do find MK4 it’s tiny portions making it not a financially viable option. Vitamin K2 helps with that by activating osteocalcin. It's like the throat is being squeezed. The “M” stands for menaquinone, a compound that is synonymous with Vitamin K2. The other main function K2 has is So i’ve just received Thorne Vitamin K2 (MK4). OPcc2_01 upvotes · comment Then there’s the issue of which type of K2 to supplement. EDIT: Upped my dose to 5mg of K-2 MK4 and it definitely helps. The Need For However, for a very small number of us the MK7 form of Vitamin K2 might cause trouble sleeping and here’s why. Evidently Vitamin K2 seems to prevent atherosclerosis. MK7 converts to MK4 in the body too. Why? Because if you take adequate vitamin D3 your gut micro biome will produce adequate amounts of it. There are other forms of K2: Mk-4, Mk-9, and others. I see supps though that are only k2 mk4 version though and people saying they are having great results. Skin and teeth feel great, not sure about any hair difference. However K2 mk4 helps maintaining bone strength at the site of the femoral neck (hip) in postmenopausal As mentioned previously, the two best-studied forms of K2 are MK-4 and MK-7. The capsules are soy free Vitamin K1 is said to be a poor form of Vitamin K, with the claim being it can only affect blood clotting, but not calcium/bone metabolism - whereas K2 (MK4/MK7) is claimed to be able to do both. /day is seen as a more useful level for osteopenia / osteoporosis patients. See this wiki as well: Because MK-7 remains in the circulation for several days, a far smaller amount of MK-7 is needed (about 100 mcg per day for MK-7 versus 15,000 mcg every 6-8 hours for MK-4), plus MK-7 taken daily builds up a Anecdotally, it seems a number of people, including myself,have had side effects from K2-MK7 supplements. Serum vitamin K 2 levels were compared after consecutive administration of MK-4 and MK-7 (60 μg/day) for 7 days. I read many reports of users developing arrhythmias when supplementing mk7 form, but apparently mk4 is not very bio available. I still get snow but much less. i found one combo mk4+mk7 on amazon and one single mk4 on iherb, but that has only 5mg per capsule and quite expensive. Some think mk7 is better, because there is a study which says that mk7 supplementation causes a rise in mk7 blood levels, but mk4 supplementation doesnt cause a rise in mk4 blood levels. The dosage says ‘one serving: 15 drops’ that equals to 15000mcg of K2, which would be 12,500% DV I would honestly just stick to one drop every other day (1000mcg per drop) and i do get a small amount from diet. in fact mk7 supplementation can lead to higher mk4 levels in certain tissues when compared to mk4 supplementation. I think that's the reason why people get palpitations with K2 MK7 but I have never seen it mentioned. Vitamin K2 (MK4, but not MK7 or vitamin K1) has also been shown to prevent bone loss and/or fractures in the following circumstances: caused by corticosteroids (e. Hours) Higher Activity Than K1 (6X in vitro) Get the Reddit app Scan this QR code to download the app now. Vitamin K2 from animal sources is MK-4, while K2 produced by bacterial fermentation as found in natto or cheese is MK-7. This also never said that taking MK4 increased the serum blood levels of MK7, nor did it say the converse. https://pubmed. Mk4 is not absorbed very well by our guts so the dosage of mk4 necessary to enter our bloodstream is wayyyyy higher than brands like NOW will provide. I mean obviously do some experimentation to make sure. Q&A. Vitamin K2 MK-4 and Trans Mk-7 Vitamin K2 Supplement: Innovix Vitamin K2 600mcg contains MK-4 + MK-7 and has a total of 600 mcg of K2 per capsule. For the past 6 months I have used MK7 for the first 2 months (90mcg/day Jarrow's) and then MK4 for the the next 2 months (3mg/day, Thorne), then switched back to MK7. Is this really that big of a deal though? It could be some kind of histamine overload response. This Reddit post for example says: . If the number is 4 (or below) it is called "short chain" and if the number is over 4 it is called "long chain". Or check it out in the app stores No, D3/K2 with MK4 instead of MK7 on January 19th. I also do a lot of intermittent fasting in addition to eating a lot of fermented vegetables to ensure a healthier gut. its the same size as the thorne 3-K capsule, and much bigger than the 15mg MK4 relentless improvement capsule. The number in the name of each type of vitamin K2 indicates how many carbon atoms there are in the sidechain or tail. 5mg vs 5mg vs 45mg) MK7 is poorly absorbed and circulates endlessly in the body until it is reduced to an active form, it is MK4 with a "long tail" I take 30,000 IU a day. I’ve heard that without Vitamin K2, calcification in soft tissue can occur. K2-Mk7 Properties and Benefits: Absorbs better than Mk4. To be very generic, MK7 has a higher bioavailability and requires lower dosing, and may be more effective. Edit: I just did a quick search on PubMed on mk-7 and this is what I read: "MK-7 increases bone mineral density and promotes bone quality and strength. Mk4 vs mk7. Tons of people have had great results with mk4, and do get Life Extension mega vitamin k2 with 45mg of k2 rather than others with just 1mg. So I like to combine them in a single supplement. I found k2 45 mg from life extension but it is way too much and also expensive broo I also found super k but i contains 1500 mcg k1, 1000 mcg k2 mk4, 100 mcg k2 mk7 But it's nothing compared to your 5000mcg mk4, please advise me if you have another recommendation, gotta try this bro thank you brother I also got super itchy with k2 so i stopped taking it. Get the Reddit app Scan this QR code to download the app now For a couple of years I was supplementing with Vitamin D3 (5000iu) and K2 (90-100mcg MK7), plus Magnesium. Unfortunately, some synthetic K2 supplements contain inactive cis isomers and you will get no benefit from them. Please help, thanks! If you find this information valuable, please like and share the video and subscribe to my channel!Also subscribe to my Substack, where I most often put out Yep, thanks again for sharing. nlm. Vitamin K2 MK7 question . gov/30816822/ Vitamin K2 (both MK4 and MK7) is very difficult to obtain from diet alone in the high doses that people supplement to try to prevent calcification. Because Genesis BioHealth is committed to offering you the safest, most effective products for the lowest daily cost, we utilize the MK4 Statins inhibit the effects of Vitamin K2, which include reducing vascular calcification to an extent. Has a long half-life in the blood of 2-3 days. From my understanding the downside of mk4 is that it's synthetic when taken in the form of a supplement. MK4 doesn't even show up in blood tests/doesn't seem to have a strong effect below 1. ncbi. NOW is making the same mistake a lot of supplements do, they take the full Vitamin K RDA and then apply it to just K2-MK4 regardless of the form. An 2013 study , performed on both mice and humans, has invalidated this claim. " The Danish Study Anybody know a good supplement where both d3 and k2 are included. But isn't there are difference in recommended dosage between K2 MK4 and MK7? I am taking Thorne Research K2 MK4 for which Thorne suggests 15 mg per day (15 drops). They say they don't get them with MK4, which makes me think maybe MK4 just doesn't work. I'd probably take much more k2 The induction of GDF15 and STC2 is likely specific to MK-4, as it was not exerted by another vitamin K 2 isoform MK-7, vitamin K 1, or the MK-4 side chain structure geranylgeraniol”. All seemed well, and I never noticed any problems with these. Typical dose to take with Vitamin D3 5000 IU per day is Vitamin K2 MK7 - 100-200mcg Vitamin K2 prevents calcium going to the wrong places - so it doesn't get deposited in soft tissue, plaque on blood vessel walls - but so Calcium goes to bones etc. MK7 carboxylates osteocalcin completely at a dose of approximately 300mcg, so Masterjohn's 200mcg of MK7 is reasonable and what a lot of MK7 supplements have in them. 5 mg. According to Weston A Price's research, k2 mk4 specifically is more vital to your health than any other variant of vitamin k. Or check it out in the app stores ideally you should be ingesting both mk4 and mk7 (and some k1), but it’s unfortunately very rare to find both in one, especially one with d3 as As this is the maximum daily amount, it is necesarry to combine this with 180 micrograms K2 as MK-7 (menaquinone-7). Neither need to be taken daily since they are fat soluble. If you are more concerned with health take MK4. The French paradox is due to their consumption of natural source K2 MK4 in the form of foie gras (goose liver) and duck fat. As much magnesium as you can tolerate is a good idea. However, consecutive administration of MK-7 increased serum MK-7 levels significantly in all subjects.
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